Investigation on SARS-Cov-2 immune escape-related spike mutations

Breeze Mancheng Hong

doi:10.1117/12.3000119

7 September 2023 Investigation on SARS-Cov-2 immune escape-related spike mutations

Breeze Mancheng Hong

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127891K (2023) https://doi.org/10.1117/12.3000119
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

SARS-Cov-2 has been widely spreading and mutating since its first emergence in December 2019. There are 5 Variantso of Concern (VOC) by February 2022. Among them, Omicron was reported to have an unprecedented number of 32 spike mutations. It was also revealed to have a strong ability in escaping immune protections from either existing vaccines or previous antibodies. In addition, its sub-lineages (BA.1, BA.2, BA.4, and BA.5) demonstrate similar increase patterns in immune escape ability. This poses a thorny problem for researchers developing vaccines and control measures for the pandemic as it significantly undermines the effectiveness of existing vaccines. In the research, we used phylogenetic analyses and mutation analyses. We found that the number of mutations and percentages of spike mutations is the foundations for high immune escape abilities of the later emerged lineages/sublineages however the determining factor relies more on the location of the mutation. Based on this discovery, we identified 8 spike mutations K417N, S477N, N501Y, Q493R, N440K, Q498L, Y505D, and F486V that are essential for increased immune escape capability.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Breeze Mancheng Hong "Investigation on SARS-Cov-2 immune escape-related spike mutations", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127891K (7 September 2023); https://doi.org/10.1117/12.3000119

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available