Demonstration of a combined multispectral FLIm/polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions

Julien Bec; Xiangnan Zhou; Martin Villiger; Brett Bouma; Laura Marcu

doi:10.1117/12.3003560

13 March 2024 Demonstration of a combined multispectral FLIm/polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions

Julien Bec, Xiangnan Zhou, Martin Villiger, Brett Bouma, Laura Marcu

Author Affiliations +

Proceedings Volume 12819, Diagnostic and Therapeutic Applications of Light in Cardiology 2024; 1281908 (2024) https://doi.org/10.1117/12.3003560
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We report the development and characterization of a multispectral FLIm/ polarization-sensitive OCT intravascular imaging catheter system. Key innovations include a high return loss rotary junction. The combined imaging contrasts target the improved characterization of inflammation and disruption of the extracellular matrix, two key contributors to atherosclerosis, by enabling the evaluation of biochemical signatures, birefringence, and depolarization in addition to lesion morphology. We present key aspects of the system’s design and performance and highlight challenges associated with the development of intravascular imaging systems suitable for clinical translation.

Conference Presentation

Citation Download Citation

Julien Bec, Xiangnan Zhou, Martin Villiger, Brett Bouma, and Laura Marcu "Demonstration of a combined multispectral FLIm/polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions", Proc. SPIE 12819, Diagnostic and Therapeutic Applications of Light in Cardiology 2024, 1281908 (13 March 2024); https://doi.org/10.1117/12.3003560

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