Hand-held optical coherence tomography endoscope and stitching algorithm for imaging the human cochlea via the round window

Julianna Bordas; Wihan Kim; Michael Serafino; Jack Tang; Dorothy W. Pan; John Oghalai; Brian E. Applegate

doi:10.1117/12.3005704

12 March 2024 Hand-held optical coherence tomography endoscope and stitching algorithm for imaging the human cochlea via the round window

Julianna Bordas, Wihan Kim, Michael Serafino, Jack Tang, Dorothy W. Pan, John Oghalai, Brian E. Applegate

Author Affiliations +

Proceedings Volume 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; 128300O (2024) https://doi.org/10.1117/12.3005704
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Magnetic Resonance Imaging and x-ray Computed Tomography have limitations when applied to diseases of the human inner ear due to insufficient resolution. Key morphological features of the inner ear are below the resolving power of both modalities; thus, they are unable to measure functional aspects of the microstructures in the cochlea. Furthermore, general access to the cochlea is a challenge due to its location in the inner ear and its bony encapsulation. These limitations cause clinicians to rely on clinical history when diagnosing and managing hearing loss in patients, which is not ideal. This paper explores the application of Optical Coherence Tomography (OCT) as a diagnostic tool for inner ear diseases. OCT’s high spatial and temporal resolution allows for detailed imaging of inner ear structures and their function. To address the challenge of accessing the cochlea in humans, a hand-held endoscopic OCT device has been developed that can image through the round window membrane. The technology has been tested in cadaver temporal bone, enabling functional and morphological imaging of the cochlea when navigated to the round window. Alongside the device, we are developing an algorithm to perform subsequent stitching of volumes to overcome limitations with a small field of view. Applying this algorithm on cadaver tissue serves as a preliminary step before advancing to live human cochlear imaging. By utilizing our hand-held OCT endoscope, clinicians will have the ability to record changes in morphological and functional information, thereby improving the approach to diagnosing and treating patients with inner ear diseases.

Conference Presentation

Citation Download Citation

Julianna Bordas, Wihan Kim, Michael Serafino, Jack Tang, Dorothy W. Pan, John Oghalai, and Brian E. Applegate "Hand-held optical coherence tomography endoscope and stitching algorithm for imaging the human cochlea via the round window", Proc. SPIE 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, 128300O (12 March 2024); https://doi.org/10.1117/12.3005704

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