Camera selection for speckle contrast optical spectroscopy and validation against diffuse correlation spectroscopy

Tom Y. Cheng; Byungchan Kim; Bernhard B. Zimmermann; Mitchell B. Robinson; Marco Renna; Stefan A. Carp; Maria Angela Franceschini; David A. Boas; Xiaojun Cheng

doi:10.1117/12.3000411

12 March 2024 Camera selection for speckle contrast optical spectroscopy and validation against diffuse correlation spectroscopy

Tom Y. Cheng, Byungchan Kim, Bernhard B. Zimmermann, Mitchell B. Robinson, Marco Renna, Stefan A. Carp, Maria Angela Franceschini, David A. Boas, Xiaojun Cheng

Author Affiliations +

Proceedings Volume 12841, Dynamics and Fluctuations in Biomedical Photonics XXI; 1284105 (2024) https://doi.org/10.1117/12.3000411
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Speckle contrast optical spectroscopy (SCOS) is an emerging camera-based technique that can measure human cerebral blood flow (CBF) noninvasively with high signal-to-noise ratio (SNR). A noise correction procedure has previously been developed to improve SCOS measurement accuracy, which requires precise characterization of camera properties. Here, we provide guidance on choosing and characterizing a camera for SCOS, considering factors such as linearity, read noise, and gain. We then validate a noise-corrected SCOS measurement of flow changes in a liquid phantom against diffuse correlation spectroscopy (DCS).

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Tom Y. Cheng, Byungchan Kim, Bernhard B. Zimmermann, Mitchell B. Robinson, Marco Renna, Stefan A. Carp, Maria Angela Franceschini, David A. Boas, and Xiaojun Cheng "Camera selection for speckle contrast optical spectroscopy and validation against diffuse correlation spectroscopy", Proc. SPIE 12841, Dynamics and Fluctuations in Biomedical Photonics XXI, 1284105 (12 March 2024); https://doi.org/10.1117/12.3000411

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