Determining total hemoglobin in blood irrespective of hemolysis status using a high-power LED-based low-cost photoacoustic system

Soumyodeep Banerjee; Sandip Sarkar; Shaibal Saha; Subhajit Karmakar

doi:10.1117/12.3002960

12 March 2024 Determining total hemoglobin in blood irrespective of hemolysis status using a high-power LED-based low-cost photoacoustic system

Soumyodeep Banerjee, Sandip Sarkar, Shaibal Saha, Subhajit Karmakar

Author Affiliations +

Proceedings Volume 12842, Photons Plus Ultrasound: Imaging and Sensing 2024; 1284215 (2024) https://doi.org/10.1117/12.3002960
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Continuous monitoring of total hemoglobin (THb) for the patients suffering from hematological or non-hematological diseases, snake bite, going through surgeries etc., finds immense clinical importance since Hb transports oxygen to the living tissues while being encapsulated within a red blood cell (RBC). Several techniques based on the electrical or chemical and or optical measurements have already been developed to determine total hemoglogin (THb) in blood. Many of them are clinically practiced. But, the very first step of processing which is common to all of them requires extraction of blood sample through venipuncture. That process is invasive, needs trained professional. A non-invasive, real-time, diagnostic tool is rather preferred especially for repeated testing. Having above two capabilities, a photoacoustic (PA) system with near-infrared illumination was previously proposed for THb determination. But a recent study on hemolysis monitoring with a low-cost NIR-PA system suggests that THb determination through NIR-PA requires apriori knowledge of hemolysis status of the sample. The question therefore remains if PA is at all suitable for this purpose. Additionally, in order to become more accessible to the patients, any such device must be portable, ergonomic and cost effective enough, which, in PA, rejects the use of bulky, expensive Nd:YAG or dye LASERs, leaving the power of the optical source limited. The present study reports a high-power LED based low-cost PA system with blue (456.5 nm) illumination that enables PA to determine total hemoglobin in blood irrespective of hemolysis status.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Soumyodeep Banerjee, Sandip Sarkar, Shaibal Saha, and Subhajit Karmakar "Determining total hemoglobin in blood irrespective of hemolysis status using a high-power LED-based low-cost photoacoustic system", Proc. SPIE 12842, Photons Plus Ultrasound: Imaging and Sensing 2024, 1284215 (12 March 2024); https://doi.org/10.1117/12.3002960

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available