The progress of optional targets and approaches to enhance efficacy of CAR-T for pancreatic ductal adenocarcinoma

Haoyun Xie

doi:10.1117/12.3012936

8 January 2024 The progress of optional targets and approaches to enhance efficacy of CAR-T for pancreatic ductal adenocarcinoma

Haoyun Xie

Author Affiliations +

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129241I (2024) https://doi.org/10.1117/12.3012936
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Pancreatic ductal adenocarcinoma (PDAC) constitutes the majority of pancreatic cancer which is one of the most lethal cancers all over the world. Due to the malignancy of PDAC with concealed property, the treatment choices were limited. Chimeric antigen receptor T cells (CAR-T) were applied to treat PDAC in clinical and preclinical trials to offer more opportunities. The burdens of CAR-T for PDAC such as tumor immunosuppressive microenvironment and off-tumor toxicity are being strived to address. Novel targets of CAR-T cells with multiple targeting, new designs of CAR and combination therapies give the treatment more options and possibility, which may contribute to improvement of CAR-T therapy for PDAC.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Haoyun Xie "The progress of optional targets and approaches to enhance efficacy of CAR-T for pancreatic ductal adenocarcinoma", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129241I (8 January 2024); https://doi.org/10.1117/12.3012936

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