Novel strategies to overcome obstacles in the solid tumour microenvironment for CAR-T cell therapy

Yiwen Gui

doi:10.1117/12.3012919

8 January 2024 Novel strategies to overcome obstacles in the solid tumour microenvironment for CAR-T cell therapy

Yiwen Gui

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129242W (2024) https://doi.org/10.1117/12.3012919
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

By harnessing the power of the patient’s immune system to recognize and eliminate cancer cells, chimeric antigen receptor T (CAR-T) cells represent a paradigm shift in cancer treatment. The FDA approval of CAR-T represents a significant milestone in the field of cancer therapy, as it provides a promising treatment option for patients with refractory or relapsed cancer who have exhausted all conventional treatment modalities. However, the internal obstacles of the tumour microenvironment (TME) have hindered its success, especially for solid tumours, as it poses several barriers to preventing the activity of CAR-T therapy. The aspects of the TME that have hampered CAR-T cell efficacy along with suggestions for the future will be reviewed in this paper. Several research has been conducted to investigate possible novel approaches to overcome the obstacles presented when dealing with solid tumours. Recent advances in the field of CAR-T therapy have led to development of innovative strategies to improve the capacity of CAR-T cells to infiltrate solid tumours. These approaches involve either local administration or targeting angiogenesis to overcome physical barriers. Novel engineering methods of CAR-T cells have also been highlighted by targeting immunosuppressive factors. In addition, approaches focusing on simultaneous stimulation of bystander endogenous antitumour responses have also been investigated. In-depth studies of the application of CAR-T therapy in solid tumour and tackling the existing obstacles are of great value for the long-term strategy of treating cancer patients in a more efficient way.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Yiwen Gui "Novel strategies to overcome obstacles in the solid tumour microenvironment for CAR-T cell therapy", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129242W (8 January 2024); https://doi.org/10.1117/12.3012919

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KEYWORDS

Solids

Cancer

Animal model studies

Clinical trials

Oncology

Engineering

Toxicity

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