Spectral photon-counting CT for quantification of iodized oil in mouse tumors

Yuedong Liu; Qiong Xu; Xuan Zhou; Cunfeng Wei; Long Wei

doi:10.1117/12.3006178

1 April 2024 Spectral photon-counting CT for quantification of iodized oil in mouse tumors

Yuedong Liu, Qiong Xu, Xuan Zhou, Cunfeng Wei, Long Wei

Proceedings Volume 12925, Medical Imaging 2024: Physics of Medical Imaging; 129252O (2024) https://doi.org/10.1117/12.3006178
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Conference Poster

Abstract

Spectral Photon-Counting CT (SPCCT) has become the focus of researchers, because of its energy resolution ability. SPCCT has broad application prospects, especially in the field of medical imaging. In medicine, iodized oil is often used as an antitumor drug, and its diffusion and retention time in tumors greatly affect the effect of tumor treatment. It's becoming an increasing concern for researchers, therefore, it is necessary to quantify the distribution and content of iodized oil in the tumor. In this study, the distribution and content of iodized oil in tumors of living mice were quantitatively analyzed with SPCCT, and an effective and convenient method based on SPCCT was established. First, using iodized oil and water as the base materials, the method of material decomposition was carried out to obtain the decomposed image of iodized oil. Then the content of iodized oil was calculated from the decomposed images, and the change of iodized oil content with time was quantitatively analyzed. The experimental results show that the quantification method of iodized oil based on SPCCT established in this study could effectively quantify the change in the distribution and content of iodized oil over a long period, indicating the potential of SPCCT in the application of drug quantitative analysis.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Yuedong Liu, Qiong Xu, Xuan Zhou, Cunfeng Wei, and Long Wei "Spectral photon-counting CT for quantification of iodized oil in mouse tumors", Proc. SPIE 12925, Medical Imaging 2024: Physics of Medical Imaging, 129252O (1 April 2024); https://doi.org/10.1117/12.3006178

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