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The purpose of the work is to demonstrate the effectiveness of optical diagnostics of cytological smears of the cervix for the presence of HPV using spectral-polarization methods. 30 cytological smears of the cervix with koilocytosis and 15 samples without koilocytosis were studied. Comparison of the obtained results with the viral load of HPV genomic equivalents in a smear-scraping by the PCR method, it was established that at wavelengths of 405-425 nm, less than 3 HE and 100 thousand cells correspond (clinically insignificant result). In contrast, at wavelengths of 425-440 nm corresponds to more than 5 HE per 100 thousand cells, which is a clinically significant variant (high carcinogenic risk). On the basis of the conducted research, it was established that the use of spectro-polarization research and the fluorescence method allows to increase the accuracy of the selection of patients for an expensive procedure - DNA diagnosis of HPV with a high carcinogenic risk by the standard PCR method.
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