Insulin detection using plasmonic optical fiber chips: a benchmark

Médéric Loyez; Hadrien Fasseaux; Ruddy Wattiez; Christophe Caucheteur

doi:10.1117/12.3017365

20 June 2024 Insulin detection using plasmonic optical fiber chips: a benchmark

Médéric Loyez, Hadrien Fasseaux, Ruddy Wattiez, Christophe Caucheteur

Proceedings Volume 13008, Biophotonics in Point-of-Care III; 130080D (2024) https://doi.org/10.1117/12.3017365
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Plasmonic optical fiber-based biosensors are currently in their early stage of development as practical and integrated devices, gradually making their way towards the biosensing market. While the majority of these plasmonic biosensors operate using white light sources and glass prisms or multimode optical fibers (OFs), our approach centers on single-mode OFs coupled with tilted fiber Bragg gratings (TFBGs) in the near-infrared wavelength range. Our objective is to enhance surface sensitivity and broaden sensing capabilities of OF-based sensors to develop in situ sensing with remote interrogation. In this study, we comprehensively assess their performance in comparison to the gold-standard plasmonic reference, a commercial device based on the Kretschmann-Raether prism configuration, namely the Biacore X100. We present their respective refractive index sensitivity and their efficiency for insulin detection using a dedicated microfluidics approach. By optimizing a consistent surface biotrapping methodology, we elucidate the dynamic facets of both technologies and highlight their remarkable sensitivity to variations in both bulk and surface properties. The one-to-one comparison between both technologies demonstrates the reliability of optical fiber-based measurements, showcasing similar experimental trends obtained with both the prismatic configuration and gold-coated TFBGs, with an even enhanced limit of detection for the latter. This study lays the foundation for the detection of punctual molecular interactions and opens the way towards the detection of spatially and temporally localized events on the surface of optical probes, paving the way for their implementation in field conditions.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Médéric Loyez, Hadrien Fasseaux, Ruddy Wattiez, and Christophe Caucheteur "Insulin detection using plasmonic optical fiber chips: a benchmark", Proc. SPIE 13008, Biophotonics in Point-of-Care III, 130080D (20 June 2024); https://doi.org/10.1117/12.3017365

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available