Biospeckle optical coherence tomography in visualizing the repetitive hot-cold response of skin age related difference

Ryosuke Nakasako; Jun Yamada; Takahiro Kono; Hirofumi Kadono; Uma Maheswari Rajagopalan

doi:10.1117/12.3021703

18 June 2024 Biospeckle optical coherence tomography in visualizing the repetitive hot-cold response of skin age related difference

Ryosuke Nakasako, Jun Yamada, Takahiro Kono, Hirofumi Kadono, Uma Maheswari Rajagopalan

Author Affiliations +

Proceedings Volume 13010, Tissue Optics and Photonics III; 130100R (2024) https://doi.org/10.1117/12.3021703
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Elasticity of blood vessels makes them contract or dilate in regulating the body temperature to changes in external temperature changes such as air-conditioning. However, ageing makes them gradually lose elasticity, making it difficult for blood vessels to make adjustments. In this study, we propose the use of biospeckle Optical Coherence Tomography (b-OCT) to visualize the dynamic changes within the skin. A total of 20 subjects with equal number of male and female particpants with ten in their 20’s and the other ten subjects in their 30’s or older were subjected to heating of the palmar forearm of their dominant hand by a USB hot pad (40°C) for five minutes. A swept source OCT (SS-OCT) operating with a central wavelength of 1310nm, a bandwidth of 125 nm and a sweep frequency of 20kHz was used to obtain OCT structural images at 12fps. From the OCT structural images obtained before and after heating, biospeckle contrast was calculated from the temporal variation in the images and compared. Biospeckle contrast results were compared for the depth, gender, and age differences. With heating, a clear difference of increased contrast was observed at shallower depths in comparison to deeper regions for both genders, while, as a whole, a larger contrast difference was observed for male in comparison to female participants. Furthermore, in the age group larger than 30, the contrast change with change in environment was smaller, suggesting the loss of elasticity to adjust to the environmental changes.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Ryosuke Nakasako, Jun Yamada, Takahiro Kono, Hirofumi Kadono, and Uma Maheswari Rajagopalan "Biospeckle optical coherence tomography in visualizing the repetitive hot-cold response of skin age related difference", Proc. SPIE 13010, Tissue Optics and Photonics III, 130100R (18 June 2024); https://doi.org/10.1117/12.3021703

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