Development and characterization of a hyperspectral LCTF-based colposcopic system

Carlos Vega; Nerea Marquez-Suarez; Raquel Leon; María Castro-Fernandez; Guillermo V. Socorro-Marrero; Himar Fabelo; Jorge Rial-Ferrario; Gustavo M. Callico

doi:10.1117/12.3017399

18 June 2024 Development and characterization of a hyperspectral LCTF-based colposcopic system

Carlos Vega, Nerea Marquez-Suarez, Raquel Leon, María Castro-Fernandez, Guillermo V. Socorro-Marrero, Himar Fabelo, Jorge Rial-Ferrario, Gustavo M. Callico

Author Affiliations +

Proceedings Volume 13016, Liquid Crystals Optics and Photonic Devices; 130160E (2024) https://doi.org/10.1117/12.3017399
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

The early detection of precancerous cervical lesions is essential to improve patient treatment and prognosis. Hyperspectral (HS) imaging (HSI) has demonstrated a high potential to become a new non-invasive and label-free imaging technique in the medical field for performing quick diagnosis of different diseases. This study presents the research and development process to integrate and characterize a KURIOS-XE2 filter (Thorlabs, Inc., NJ, USA), based in a liquid crystal tunable filter (LCTF) technology, into an existing colposcope (C5, OPTOMIC, Spain). The main goal was to capture spectral information in the near infrared range (650 to 1100nm) by using a monochrome camera and acquiring 90 spectral wavelengths with a spectral resolution of 5nm. Two different integration strategies were studied: i) filtering the emitted light by the sensor and ii) filtering the received light by the sensor, evaluating their respective benefits and limitations. Furthermore, a custom software was developed for HS image acquisition, integrating a variable acquisition time per wavelength, which allows improving the signal-to-noise ratio at wavelengths where the system presents lower quantum efficiency. The proposed system simplifies the adaptation of existing optical systems to HSI technology, improving the signal-to-noise ratio in the studied spectral range respect to other approaches. The results were compared against a previous custom implementation based on a Snapscan camera (IMEC, Belgium), covering the visual and near infrared and highlighting the advantages and limitations of both technologies for the development of a HS colposcope system targeting early detection of precancerous cervical lesions during routine clinical practice.

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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Carlos Vega, Nerea Marquez-Suarez, Raquel Leon, María Castro-Fernandez, Guillermo V. Socorro-Marrero, Himar Fabelo, Jorge Rial-Ferrario, and Gustavo M. Callico "Development and characterization of a hyperspectral LCTF-based colposcopic system", Proc. SPIE 13016, Liquid Crystals Optics and Photonic Devices, 130160E (18 June 2024); https://doi.org/10.1117/12.3017399

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