Exploring alterations in low-frequency bands with frequency dependence amplitudes within major depressive disorder

Sifan Wang; Ming Ke

doi:10.1117/12.3036616

13 July 2024 Exploring alterations in low-frequency bands with frequency dependence amplitudes within major depressive disorder

Sifan Wang, Ming Ke

Author Affiliations +

Proceedings Volume 13208, Third International Conference on Biomedical and Intelligent Systems (IC-BIS 2024); 132081T (2024) https://doi.org/10.1117/12.3036616
Event: 3rd International Conference on Biomedical and Intelligent Systems (IC-BIS 2024), 2024, Nanchang, China

Abstract

In our research, we obtained resting-state functional magnetic resonance imaging (rs-fMRI) data from 23 newly diagnosed, drug-free Major Depressive Disorder (MDD) patients and 20 age- and sex-matched healthy controls (HC). We examined Amplitude of Low Frequency Fluctuation (Alff) and fractional Alff (fAlff) across various frequency ranges to assess frequency-specific neural modifications associated with MDD sufferers. The investigation was conducted across the entire brain, avoiding the limitations of seed-based approaches, which are constrained to predefined brain areas. We found that certain regions, particularly those with varying spatial patterns across frequencies like the medial prefrontal cortex, showed more pronounced abnormalities in specific frequency ranges. These findings suggest improved methods for detecting functional brain changes in MDD.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Sifan Wang and Ming Ke "Exploring alterations in low-frequency bands with frequency dependence amplitudes within major depressive disorder", Proc. SPIE 13208, Third International Conference on Biomedical and Intelligent Systems (IC-BIS 2024), 132081T (13 July 2024); https://doi.org/10.1117/12.3036616

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KEYWORDS

Brain

Control systems

Prefrontal cortex

Brain diseases

Functional magnetic resonance imaging

Mental disorders

Neuroimaging

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