Enantio-selective optode for the B-blocker propranolol

Huarui He; Georg Uray; Otto S. Wolfbeis

doi:10.1117/12.24805

1 March 1991 Enantio-selective optode for the β-blocker propranolol

Huarui He, Georg Uray, Otto S. Wolfbeis

Proceedings Volume 1368, Chemical, Biochemical, and Environmental Fiber Sensors II; (1991) https://doi.org/10.1117/12.24805
Event: SPIE Microelectronic Interconnect and Integrated Processing Symposium, 1990, San Jose, United States

Abstract

We present a scheme for sensing optical isomers (enantiomers) of biogenic amines such as the Bblocker propranolol. Recognition of one of the enantiomers of propranolol is accomplished by specific interaction of the amine (which is present in the protonated ammonium form at physiological pH) with an optically active substrate (dibutyl tartrate) in a pvc membrane. As the ammonium ion is carried into the pvc membrane a proton is simultaneously released from the proton carrier (a lipophilic phenolic xanthene dye which undergoes protolytic dissociation in the pvc membrane) which thereby suffers a color change. The sensor responds to propranolol but also to other biogenic amines such as 1-phenylethylamine and norephedrine in the 20 pM to 10 mM range but has a pH-dependent response. The selectivity factors depend on the type of receptor and range from 0. 0 to 0. 30.

Citation Download Citation

Huarui He, Georg Uray, and Otto S. Wolfbeis "Enantio-selective optode for the β-blocker propranolol", Proc. SPIE 1368, Chemical, Biochemical, and Environmental Fiber Sensors II, (1 March 1991); https://doi.org/10.1117/12.24805

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