Clinical, MRI, and histological results after photodynamic therapy of oral cancer

Michael Herzog; Ch. Fellbaum; C. Wagner-Manslau; Hans-Henning Horch

doi:10.1117/12.60927

1 June 1992 Clinical, MRI, and histological results after photodynamic therapy of oral cancer

Michael Herzog, Ch. Fellbaum, C. Wagner-Manslau, Hans-Henning Horch

Proceedings Volume 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy; (1992) https://doi.org/10.1117/12.60927
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Twenty-one carcinomas of the oral cavity in 18 patients were treated by photodynamic therapy (PDT). Patients were sensitized with Photosan III (2 mg/kg body weight), a modified HPD. Forty-eight hours after application of Photosan III, the tumor and surrounding tissues were irradiated with red laser light (200 mW/cm2, 120 J/cm2). MRI controls were carried out 24 hours after irradiation. Three to five days after irradiation, tumors were removed by conventional surgery. All specimens underwent histological examination. Histologically, hemorrhagic necroses of the irradiated tumors was found in all cases. The depth of necrosis varied from 2 to 8 mm. By MRI controls it was possible to detect edemas as change of signal resonance. PDT is a reliable therapy to reduce oral cancer selectively. Cancer destruction is limited by penetration depth of the laser light.

Citation Download Citation

Michael Herzog, Ch. Fellbaum, C. Wagner-Manslau, and Hans-Henning Horch "Clinical, MRI, and histological results after photodynamic therapy of oral cancer", Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); https://doi.org/10.1117/12.60927

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