Prospect of relieving pain due to tooth movement during orthodontic treatment utilizing a Ga-Al-As diode laser

Noriyoshi Shimizu; Masaru Yamaguchi; Takemi Goseki; Yasuko Shibata; Hisashi Takiguchi; Yoshimitsu Abiko; Tadamasa Iwasawa

doi:10.1117/12.207039

17 April 1995 Prospect of relieving pain due to tooth movement during orthodontic treatment utilizing a Ga-Al-As diode laser

Noriyoshi Shimizu, Masaru Yamaguchi, Takemi Goseki, Yasuko Shibata, Hisashi Takiguchi, Yoshimitsu Abiko, Tadamasa Iwasawa

Author Affiliations +

Proceedings Volume 1984, Advanced Laser Dentistry; (1995) https://doi.org/10.1117/12.207039
Event: Advanced Laser Dentistry, 1994, St. Petersburg, Russian Federation

Abstract

The effects of low-power laser irradiation on prostaglandin (PG)E₂ and interleukin(IL)-1(beta) production in stretched human periodontal ligament (PDL) cells were assessed in vitro. PDL cells derived from healthy premolars were utilized for these experiments. Cells were seeded in flexible-bottom culture plates and elongated (18% increase) under a vacuum at 6 cycles per minute for 1 to 5 days. The stretched cells were irradiated with a Ga-Al-As low-power diode laser (60 mW) once a day for 3 to 10 minutes for 1 to 5 days. PGE₂ and IL-1(beta) levels in the medium were measured by radio immunoassay. Human PDL cells showed a marked elevation in PGE₂ and IL-1(beta) production in response to mechanical stretching. The increase in PGE₂ production was significantly inhibited by laser irradiation in a dose-dependent manner. The increase in IL-1(beta) production was also inhibited by laser irradiation, although the inhibition was only partial under this irradiation condition. Since high levels of PGE₂ and IL-1(beta) are found in the PDL when teeth are moved during orthodontic treatment and since both factors are involved with the induction of pain, the inhibitory effects of laser irradiation on PGE₂ and IL-1(beta) production suggest that laser irradiation may have therapeutic benefits in relieving the pain that accompanies orthodontic treatment.

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Noriyoshi Shimizu, Masaru Yamaguchi, Takemi Goseki, Yasuko Shibata, Hisashi Takiguchi, Yoshimitsu Abiko, and Tadamasa Iwasawa "Prospect of relieving pain due to tooth movement during orthodontic treatment utilizing a Ga-Al-As diode laser", Proc. SPIE 1984, Advanced Laser Dentistry, (17 April 1995); https://doi.org/10.1117/12.207039

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