Dongming Cai,1 Ying-Cheng Lai,2 Raimond L. Winslow3
1Univ. of Minnesota (United States) 2Johns Hopkins Univ. School of Medicine (United States) 3Johns Hopkins Univ. School of Medicine and Univ. of Minnesota (United States)
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We investigate the dynamics of a pair of electrically coupled pacemaking sino-atrial node cells based on a physiologically detailed model. Each cell has distinguished oscillation properties. It is found that at low, yet still physiologically reasonable coupling conductance values, complex dynamics including chaos can arise. Occurrence of these complex dynamics in coupled pacemaker cells may provide an explanation for the origin of certain cardiac arrhythmias.
Dongming Cai,Ying-Cheng Lai, andRaimond L. Winslow
"Periodicity, quasiperiodicity, and chaos in coupled cardiac pacemaker cells", Proc. SPIE 2036, Chaos in Biology and Medicine, (5 November 1993); https://doi.org/10.1117/12.162726
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Dongming Cai, Ying-Cheng Lai, Raimond L. Winslow, "Periodicity, quasiperiodicity, and chaos in coupled cardiac pacemaker cells," Proc. SPIE 2036, Chaos in Biology and Medicine, (5 November 1993); https://doi.org/10.1117/12.162726