Time-resolved fluorescence spectroscopy of ether-bonded porphyrin-chlorin dimer

Oleg I. Lobanov; Serge Yu. Arjantsev; Ekaterina G. Levinson; Andrei F. Mironov

doi:10.1117/12.168651

1 March 1994 Time-resolved fluorescence spectroscopy of ether-bonded porphyrin-chlorin dimer

Oleg I. Lobanov, Serge Yu. Arjantsev, Ekaterina G. Levinson, Andrei F. Mironov

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168651
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

The ether-bonded porphyrin-chlorin dimer, that has been synthesized recently in MIFCT as an advantageous second generation photosensitizer, was investigated by steady and time-resolved fluorescence spectroscopy. Chromatography shows that dimer exists as two isomers. Absorption spectra of both isomers are similar and correspond to the overlapping spectra of the initial substances. The fluorescence spectra of isomers differ significantly. While the single fluorescence band of chlorin at 650 nm is typical for the first isomer, the second isomer is characterized by the fluorescence spectrum consisting of three bands at 620, 650, and 685 nm. These data show that there is the energy transfer from porphyrin to chlorin entity. The efficiency of the energy transfer depends on stereometric configuration of dimeric molecules. The results of fluorescence anisotropy measurements confirm the difference in the shape of isomers. The intensive delayed luminescence is an evidence of the existence of long-lived triplet state probably resulting in the high efficiency of singlet oxygen generation.

Citation Download Citation

Oleg I. Lobanov, Serge Yu. Arjantsev, Ekaterina G. Levinson, and Andrei F. Mironov "Time-resolved fluorescence spectroscopy of ether-bonded porphyrin-chlorin dimer", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168651

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