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15 February 1994 Photodynamic detection and treatment of squamous cell carcinoma
Sandor G. Vari M.D., Vani R. Pergadia, Thanassis Papaioannou, Wendy J. Snyder, J. Marcus, Edward Glassberg, L. Dimino-Emme, Michael C. Fishbein M.D., Reem Thomas, M. D. Dhondt, Gary P. Lask M.D., Warren S. Grundfest M.D.
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Proceedings Volume 2086, Medical Applications of Lasers; (1994) https://doi.org/10.1117/12.169148
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary
Abstract
In this study the fluorescence intensity of photosensitizer in squamous cell tumors were quantified in terms of the tumor resolution rate. A He-Cd laser (442 nm - 17 mW) with a 600 micrometers core silica fiber was used for excitation. The same fiber was used for fluorescence acquisition and an optical multichannel analyzer (EG&G, OMA III) was used to analyze the fluorescence. Twelve days after carcinoma inoculation fluorescence signal from the tumor and skin (1 cm radius from the tumor) at the 12, 3, 6, and 9 o'clock positions were recorded. Benzoporphyrin Derivative (QLT, Canada -- 2 mg/kg of body weight) was then injected into the tail vein. The drug was photoactivated with a 690 nm modified argon pump cw-dye laser (Medtech) operating at 140 mW/cm2 for 15 mins. LIFS is capable of localizing in situ malignancy and evaluating photosensitizers for photodynamic fluorescence detection and therapy of tumors.
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Sandor G. Vari M.D., Vani R. Pergadia, Thanassis Papaioannou, Wendy J. Snyder, J. Marcus, Edward Glassberg, L. Dimino-Emme, Michael C. Fishbein M.D., Reem Thomas, M. D. Dhondt, Gary P. Lask M.D., and Warren S. Grundfest M.D. "Photodynamic detection and treatment of squamous cell carcinoma", Proc. SPIE 2086, Medical Applications of Lasers, (15 February 1994); https://doi.org/10.1117/12.169148
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KEYWORDS
Tumors
Luminescence
Photodynamic therapy
Laser applications
Skin
Argon ion lasers
Medical laser equipment
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