Evaluation of film coating process with FTIR

Astrid Arbin; Anders Ringberg; Martin Sandberg; Jan Oestelius

doi:10.1117/12.166754

31 January 1994 Evaluation of film coating process with FTIR

Astrid Arbin, Anders Ringberg, Martin Sandberg, Jan Oestelius

Proceedings Volume 2089, 9th International Conference on Fourier Transform Spectroscopy; (1994) https://doi.org/10.1117/12.166754
Event: Fourier Transform Spectroscopy: Ninth International Conference, 1993, Calgary, Canada

Abstract

Film coating of oral solid preparations is used for tastemasking and controlled release purposes. The evaluation of the film coating process, both during product development and for in-process control, is mostly done by in-vitro dissolution studies. These studies are however rather time consuming and do not give complete information about the film properties or the surface composition of the product, which is important both in terms of drug release rates and long term stability. In this work Fourier transform infrared spectroscopy with photoacoustic detection was used for characterization of polymer films directly on the finished drug preparation. The results obtained are compared with in-vitro dissolution and electron microscopy studies.

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Astrid Arbin, Anders Ringberg, Martin Sandberg, and Jan Oestelius "Evaluation of film coating process with FTIR", Proc. SPIE 2089, 9th International Conference on Fourier Transform Spectroscopy, (31 January 1994); https://doi.org/10.1117/12.166754

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