Comparison of the influence of a water-soluble polymer carrier on the tumor localization and biodistribution of mesotetrametahydroxyphenylchlorin (mTHPC) in two animal models

P. Westermann; Thomas M. Glanzmann; S. Folli; Daniel Braichotte; Martin Forrer; Snezana Andrejevic-Blant; J.-P. Mach; Philippe Monnier; Hubert van den Bergh

doi:10.1117/12.203361

1 March 1995 Comparison of the influence of a water-soluble polymer carrier on the tumor localization and biodistribution of mesotetrametahydroxyphenylchlorin (mTHPC) in two animal models

P. Westermann, Thomas M. Glanzmann, S. Folli, Daniel Braichotte, Martin Forrer, Snezana Andrejevic-Blant, J.-P. Mach, Philippe Monnier, Hubert van den Bergh

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Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203361
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

Mesotetrametahydroxyphenylchlorin (mTHPC) is compared to mTHPC derivatized with one or more polyethyleneglycol (PEG) chains of about 6000 amu. The latter compound is called mTHPC-PEG hereafter. In particular the uptake and removal of these two compounds is studied in tumor and other tissues after injection as a function of the time. In a first model this is done with nude mice bearing human colorectal xenografts (LS174T); in a second model it is studied in a Chinese hamster with a 7,12 dimethylbenzanthracene (DMBA) induced early squamous cell carcinoma in the cheekpouch mucosa. In the nude mice with tumors grown to between 70 and 130 mg, tumor to muscle dye ratios are found to attain a maximum value of 4.8, eight hours after injection of mTHPC. With mTHPC-PEG the tumor to muscle ratio attained a value as high as 18.6, forty-eight hours after injection. In the hamster model the maximum tumor to normal mucosa ratio for mTHPC was about 3.5 at times up to 2 hours after injection. For the mTHPC-PEG this ratio is always near unity in this model.

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P. Westermann, Thomas M. Glanzmann, S. Folli, Daniel Braichotte, Martin Forrer, Snezana Andrejevic-Blant, J.-P. Mach, Philippe Monnier, and Hubert van den Bergh "Comparison of the influence of a water-soluble polymer carrier on the tumor localization and biodistribution of mesotetrametahydroxyphenylchlorin (mTHPC) in two animal models", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203361

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