Selective uptake of texaphyrins in atheromatous plaque

Kathryn W. Woodburn; Stuart W. Young M.D.; Q. Fan; David Kessel; Richard A. Miller

doi:10.1117/12.239994

17 May 1996 Selective uptake of texaphyrins in atheromatous plaque

Kathryn W. Woodburn, Stuart W. Young M.D., Q. Fan, David Kessel, Richard A. Miller

Proceedings Volume 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI; (1996) https://doi.org/10.1117/12.239994
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Texaphyrins are water soluble porphyrinoids which selectively localize in atheromatous plaque. The paramagnetic gadolinium texaphyrin is an excellent contrast agent which enables plaque detection by MRI. The diamagnetic lutetium texaphyrin, using fluorescence methods, was also shown to label atheromatous plaque. The chemical environment of bound lutetium texaphyrin within plaque was determined by fluorescence emission spectra to be predominantly lipophilic. The texaphyrin was found to bind to the lower density lipoproteins in the atherosclerotic-induced animals. Lutetium texaphyrin is an excellent candidate for photoatherolytic therapy.

Citation Download Citation

Kathryn W. Woodburn, Stuart W. Young M.D., Q. Fan, David Kessel, and Richard A. Miller "Selective uptake of texaphyrins in atheromatous plaque", Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); https://doi.org/10.1117/12.239994

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