Pecularities of clinical photodynamic therapy of cancer

Eugeny Ph. Stranadko; Oleg K. Skobelkin; Grigory Dorofeevit Litvin M.D.; Tamara A. Astrakhankina

doi:10.1117/12.229487

8 January 1996 Pecularities of clinical photodynamic therapy of cancer

Eugeny Ph. Stranadko, Oleg K. Skobelkin, Grigory Dorofeevit Litvin M.D., Tamara A. Astrakhankina

Proceedings Volume 2728, CIS Selected Papers: Laser Use in Oncology; (1996) https://doi.org/10.1117/12.229487
Event: CIS Selected Papers: Laser Use in Oncology, 1995, -, Russian Federation

Abstract

The analysis of the results of photodynamic therapy (PDT) for treating malignant neoplasms of the skin, mammary glands, tongue, oral mucous, lower lip, larynx, lungs, urinary bladder rectum and other locations has been made. During 1992 - 1995 478 tumoral foci in 125 patients have been treated with PDT. All patients were previously treated with conventional techniques without effect or they were not treated due to contraindications either because of severe accompanying diseases or because of old age. A part of the patients had PDT because of recurrences or intradermal metastases in 1 - 2 years after surgical, radial or combined treatment. Two home-made preparations were used as photosensitizers: Photohem (hematoporphyrine derivative) and Photosense (aluminum sulfonated phthalocyanine). Light sources were: the argon pumped dye laser (`Innova-200', `Coherent') and home-made laser devices: copper-vapor laser-pumped dye laser (`Yakhroma-2', Frjazino), gas-discharge unit `Ksenon' (wavelength 630 nm), gold-vapor laser (wavelength 627.8 nm) for Photohem; while for Photosense sessions we used solid-state laser on ittrium aluminate `Poljus-1' (wavelength 670 nm). Up to now we have follow-up control data within 2 months and 3 years. Positive effect of PDT was seen in 92% of patients including complete regression of tumors in 66.4% and partial in 25.6%. Currently, this new perspective technique of treating malignant neoplasms is successfully being used in Russia; new photosensitizers and light sources for PDT and fluorescent tumor diagnostics are being developed as well.

Citation Download Citation

Eugeny Ph. Stranadko, Oleg K. Skobelkin, Grigory Dorofeevit Litvin M.D., and Tamara A. Astrakhankina "Pecularities of clinical photodynamic therapy of cancer", Proc. SPIE 2728, CIS Selected Papers: Laser Use in Oncology, (8 January 1996); https://doi.org/10.1117/12.229487

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