Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry

S. Saponaro; B. Farina; Lars H. P. Murrer; Emanuele Pignoli; Raffaella Rizzo; Willem M. Star; Stefano Tomatis; Renato Marchesini

doi:10.1117/12.260721

5 December 1996 Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry

S. Saponaro, B. Farina, Lars H. P. Murrer, Emanuele Pignoli, Raffaella Rizzo, Willem M. Star, Stefano Tomatis, Renato Marchesini

Author Affiliations +

Proceedings Volume 2923, Laser-Tissue Interaction and Tissue Optics II; (1996) https://doi.org/10.1117/12.260721
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

A Monte Carlo model has been developed to simulate the fluence distribution in a fully cylindrical geometry, when a finite linear light source is placed on the axis of a hollow organ during PDT treatment. Height and radius of the cavity, scattering and absorption coefficients, anisotropy factor (g), refractive index of medium and cavity are required as input by the MC code. Data obtained from this model were subsequently compared with experimental results using a tissue simulating phantom. An aqueous solution of Intralipid-10 percent and black ink were used to simulate optical properties. A helium-neon laser, coupled to a cylindrical diffuser was employed as light source. A good agreement between the MC simulations and experimental measurements was found.

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S. Saponaro, B. Farina, Lars H. P. Murrer, Emanuele Pignoli, Raffaella Rizzo, Willem M. Star, Stefano Tomatis, and Renato Marchesini "Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry", Proc. SPIE 2923, Laser-Tissue Interaction and Tissue Optics II, (5 December 1996); https://doi.org/10.1117/12.260721

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