Interaction of 1540-nm laser radiation with skin (in vivo): morphological and histologic study

Alexei V. Lukashev; Boris I. Denker; Victor V. Engovatov; Pavel P. Pashinin; Valery P. Solovyev; Sergey E. Sverchkov

doi:10.1117/12.260724

5 December 1996 Interaction of 1540-nm laser radiation with skin (in vivo): morphological and histologic study

Alexei V. Lukashev, Boris I. Denker, Victor V. Engovatov, Pavel P. Pashinin, Valery P. Solovyev, Sergey E. Sverchkov

Proceedings Volume 2923, Laser-Tissue Interaction and Tissue Optics II; (1996) https://doi.org/10.1117/12.260724
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

The skin response was studied for different radiant exposure of short and long laser pulses and reaction to multipulse action using Er-glass laser radiation. Lesion ranging from a mild erytherma to tissue coagulation were produced on porcine skin. Radiant exposure producing 50 percent probability of a particular grade of lesion were established. A dependence of ED50 of minimum erythema versus number of pulses and beam cross section were studied. Histological investigation of the damage zone was made for qualitative study of injured skin. The dose-response relationship for producing different grades of burns were determined for energy densities of single laser pulse within the range 0.5-35 J/cm² and pulse duration 100 ns and 3 ms. The single pulse dose in a chain of repetitive pulses producing minimum erythema were determined for 2ⁿ(n equals 1-6) pulses. The minimum reaction of skin on laser irradiance were studied for different beam diameter. The reaction of skin in mostly considered as local super heating. The data obtained are adequate to update safety standards for cutaneous injury within these ranges of radiant exposure and beam spotsize.

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Alexei V. Lukashev, Boris I. Denker, Victor V. Engovatov, Pavel P. Pashinin, Valery P. Solovyev, and Sergey E. Sverchkov "Interaction of 1540-nm laser radiation with skin (in vivo): morphological and histologic study", Proc. SPIE 2923, Laser-Tissue Interaction and Tissue Optics II, (5 December 1996); https://doi.org/10.1117/12.260724

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