Laser-tissue interaction

Ashley J. Welch

doi:10.1117/12.260745

5 December 1996 Laser-tissue interaction

Ashley J. Welch

Proceedings Volume 2923, Laser-Tissue Interaction and Tissue Optics II; (1996) https://doi.org/10.1117/12.260745
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

The response of tissue to laser radiation spans the gauntlet from biostimulation at irradiance levels of mW to the violent disruptions of tissue with short pulses that have MW peak irradiances. The end result of laser interaction with tissue is governed by energy Deposition that depends upon laser parameters and tissue properties. In concept, PDT requires a laser wavelength that matches an absorption peak of the photosensitizer and a penetration depth to reach all of the targeted tissue. Dosimetry will depend upon the needed fluence rate 4(z) of the light at the targeted depth. Given the optical properties of the tissue, various methods of solving the transport equation can be used to calculate fluence rate [W1m2] as a function of depth. Since most wavelengths of interest for PDT are in the red and near IR, scattering dominates absorption; and the fluence rate just below the surface of tissue can be much larger than the irradiance, EO [W/m2].

Citation Download Citation

Ashley J. Welch "Laser-tissue interaction", Proc. SPIE 2923, Laser-Tissue Interaction and Tissue Optics II, (5 December 1996); https://doi.org/10.1117/12.260745

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