Er:YAG laser-induced changes in skin in vivo and transdermal drug delivery

Stephen Thomas Flock; Tom Stern; Paul Lehman; Scott Dinehart M.D.; Tom Franz; George Liu; Scott J. Stern M.D.

doi:10.1117/12.275068

22 May 1997 Er:YAG laser-induced changes in skin in vivo and transdermal drug delivery

Stephen Thomas Flock, Tom Stern, Paul Lehman, Scott Dinehart M.D., Tom Franz, George Liu, Scott J. Stern M.D.

Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275068
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

It has been shown that laser ablation of stratum corneum, in vitro, can result in an increased uptake of topically applied pharmaceuticals. We have performed measurements of drug permeation, using an in vitro model of human skin, that involves a portable Er:YAG laser used to ablate the stratum corneum. For the first time, this method of drug administration was tested in vivo in human volunteers, whereby a hydrocortisone blanching assay was used to assess the efficiency of the procedure. The results show that this is a safe and efficient way to ablate stratum corneum for the purpose of enhanced transcutaneous drug administration.

Citation Download Citation

Stephen Thomas Flock, Tom Stern, Paul Lehman, Scott Dinehart M.D., Tom Franz, George Liu, and Scott J. Stern M.D. "Er:YAG laser-induced changes in skin in vivo and transdermal drug delivery", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275068

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available