Comparison between near-infrared oximetry and 99mTc-HMPAO uptake in the resting peripheral muscle under normobaric normoxia and hypobaric hypoxia

Marco Pagani; Ralf Ansjon; Folke Lind; Cathrine Jonsson; Johan Uusijarvi; Gamze Sumen; Hans Jacobsson; Stig A. Larsson

doi:10.1117/12.301047

1 January 1998 Comparison between near-infrared oximetry and ^99mTc-HMPAO uptake in the resting peripheral muscle under normobaric normoxia and hypobaric hypoxia

Marco Pagani, Ralf Ansjon, Folke Lind, Cathrine Jonsson, Johan Uusijarvi, Gamze Sumen, Hans Jacobsson, Stig A. Larsson

Author Affiliations +

Proceedings Volume 3194, Photon Propagation in Tissues III; (1998) https://doi.org/10.1117/12.301047
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

We have used three different oximeters to study finger capillary SatO₂, transcutaneous oxygen tension and vastus lateralis hemoglobin saturation and hemoglobin concentration in 6 volunteers under normobaric normoxia and hypobaric hypoxia. Simultaneously, the ^99mTc-HMPAO uptake in the thigh muscles was assessed by planar scintigraphy. We found a highly selective uptake of ^99mTc-HMPAO in the muscles of all subjects thighs. ^99mTc-HMPAO uptake was significantly higher in hypoxia as compared to normoxia (p < 0.001). By comparing scintigraphy and tissue spectrophotometry (OMNIA), we observed a strong correlation between ^99mTc-HMPAO uptake and hemoglobin saturation (R equals 0.96, p < 0.001) and a good correlation between ^99mTc-HMPAO uptake and hemoglobin concentration (R equals 0.77, p < 0.05). These correlations indicate the occurrence of a protective vasodilatory response during hypobaric hypoxia. During hypoxia, none of the three methods used to measure oxygen saturation correlated with the actual arterial SatO₂. This results suggest that different body districts react to hypoxia in a non-uniform manner. The role of the used NIRS instrumentation in assessing quantitative values needs further investigations.

Citation Download Citation

Marco Pagani, Ralf Ansjon, Folke Lind, Cathrine Jonsson, Johan Uusijarvi, Gamze Sumen, Hans Jacobsson, and Stig A. Larsson "Comparison between near-infrared oximetry and ^99mTc-HMPAO uptake in the resting peripheral muscle under normobaric normoxia and hypobaric hypoxia", Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); https://doi.org/10.1117/12.301047

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available