FCLA-enhanced sonoluminescence imaging in vivo

Yonghong He; Yonghong Tang; Shici Tan; Da Xing

doi:10.1117/12.364375

17 September 1999 FCLA-enhanced sonoluminescence imaging in vivo

Yonghong He, Yonghong Tang, Shici Tan, Da Xing

Proceedings Volume 3863, 1999 International Conference on Biomedical Optics; (1999) https://doi.org/10.1117/12.364375
Event: International Symposium on Biomedical Optics, 1999, Wuhan, China

Abstract

In this paper, we report, for the first time, sonoluminescence (SL) images of living body (nude mouse) injected with and without chemical agents under weak ultrasound field. We found FCLA (Fluoresceinyl Cypridina Luminescent Analog), a chemiluminescent analytic agent, could enhance SL and can work in vivo. We also makes use of sonosensitization to produce tumor-selective oxygen radicals that can react with FCLA to emit chemiluminescence. By detecting this luminescence, we obtained a clear diagnostic image. This novel method proposed by our group has potential application in clinics for tumor early-stage diagnosis.

Citation Download Citation

Yonghong He, Yonghong Tang, Shici Tan, and Da Xing "FCLA-enhanced sonoluminescence imaging in vivo", Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); https://doi.org/10.1117/12.364375

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