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Photostability studies of porphyrin-type sensitizers performed in aqueous solutions, model systems (sensitizers bound to human serum albumin or in a suspension of released erythrocyte ghosts) and in tumor tissue reveal that similar photomodification takes place in all investigated environments: photobleaching during exposure to light is followed by the formation of red-absorbing photoproducts. Photoproducts are not formed in the solutions of the less photostable sensitizer chlorin e6 and the most photostable sensitizer aluminum phthalocyanine tetrasulphonate. Interaction with photooxidizable biomolecules increases the photobleaching rate of porphyrin-type sensitizers. This should be taken into account in the estimation of optimal photodynamic doses. The modified formula including photodestruction of sensitizer and formation of photoproduct is suggested.
Ricardas Rotomskis,Saulius Bagdonas,Petras Juzenas,Dimitry Y. Frolov, andGiedre Streckyte
"Photomodification of sensitizers commonly used in photosensitized tumor therapy", Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); https://doi.org/10.1117/12.364344
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Ricardas Rotomskis, Saulius Bagdonas, Petras Juzenas, Dimitry Y. Frolov, Giedre Streckyte, "Photomodification of sensitizers commonly used in photosensitized tumor therapy," Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); https://doi.org/10.1117/12.364344