Quantitative muscle oxygenation measurement using NIRS with correction for the influence of a fat layer: comparison of oxygen consumption rates with measurements by other techniques

Masatsugu Niwayama; Takatumi Hamaoka; Ling Lin; Jun Shao; Nobuki Kudo; Chietsugu Katoh; Katsuyuki Yamamoto

doi:10.1117/12.384911

3 May 2000 Quantitative muscle oxygenation measurement using NIRS with correction for the influence of a fat layer: comparison of oxygen consumption rates with measurements by other techniques

Masatsugu Niwayama, Takatumi Hamaoka, Ling Lin, Jun Shao, Nobuki Kudo, Chietsugu Katoh, Katsuyuki Yamamoto

Author Affiliations +

Proceedings Volume 3911, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II; (2000) https://doi.org/10.1117/12.384911
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

The inhomogeneity of tissue structure greatly affects the sensitivity of tissue oxygenation measurement by near-IR spectroscopy (NIRS). We have proposed a method for correcting the influence of a subcutaneous fat layer on muscle oxygenation measurements. In this study, we validated our correction method by measuring oxygen consumption rates of the forearm muscle and comparing the measurements with those obtained by other techniques. ³¹P-magnetic resonance spectroscopy and positron emission tomography (PET). In NIRS, Vo₂mus was obtained from the falling rate of oxygenation in ischaemia tests. The values of Vo₂mos were corrected using a curve of measurement sensitivity against fat layer thicknesses, which were measured by ultrasonography. The corrected Vo₂mus showed greater values and less variation between individuals than did the uncorrected one. In the ³¹P-NMR measurements on 10 subjects, Vo₂mus was estimated from changes in phosphocreatine. The corrected Vo₂mus in NIRS correlated well with the measurements by ³¹P-NMR compared to the uncorrected Vo₂mus. This result suggested that our correction method is valid. Vo₂mus was also measured using PET in one of the authors. The measured values by NIRS. ³¹P-NMR and PET were 0.22, 0.17, 0.24 ml 100g^-1 min^-1, respectively. The measurement by NIRS using our correction method was in an acceptable range.

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Masatsugu Niwayama, Takatumi Hamaoka, Ling Lin, Jun Shao, Nobuki Kudo, Chietsugu Katoh, and Katsuyuki Yamamoto "Quantitative muscle oxygenation measurement using NIRS with correction for the influence of a fat layer: comparison of oxygen consumption rates with measurements by other techniques", Proc. SPIE 3911, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II, (3 May 2000); https://doi.org/10.1117/12.384911

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