Integrated CT-SPECT system for small-animal imaging

Mark Bennett Williams; Guimin Zhang; Mitali J. More; Allen R. Goode; Stan Majewski; Randy F. Wojcik; Brian Kross; Vladimir Popov; Andrew G. Weisenberger; Martin J. Stanton; Walter Charles Phillips; Alexander X. Stewart; Thomas G. McCauley; Tao Wu; Edward V.R. DiBella

doi:10.1117/12.410571

18 December 2000 Integrated CT-SPECT system for small-animal imaging

Mark Bennett Williams, Guimin Zhang, Mitali J. More, Allen R. Goode, Stan Majewski, Randy F. Wojcik, Brian Kross, Vladimir Popov, Andrew G. Weisenberger, Martin J. Stanton, Walter Charles Phillips, Alexander X. Stewart, Thomas G. McCauley, Tao Wu, Edward V.R. DiBella

Author Affiliations +

Proceedings Volume 4142, Penetrating Radiation Systems and Applications II; (2000) https://doi.org/10.1117/12.410571
Event: International Symposium on Optical Science and Technology, 2000, San Diego, CA, United States

Abstract

We are developing a scanner for simultaneous acquisition of x-ray computed tomography (CT) and single photon emission tomography (SPECT) images of small animals such as mice and rats. The scanner uses a cone beam geometry for both the x- ray transmission and gamma emission projections by using an area x-ray detector and pinhole collimator, respectively. The CT and SPECT data set are overlaid to form a coregistered structural-functional 3D image. The CT system includes a single CCD-based x-ray detector and a microfocus x-ray source. The SPECT scanner utilizes tungsten pinhole collimators and arrays of CsI(Tl) scintillation detectors. We describe considerations and the early performance of a prototype scanner.

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Mark Bennett Williams, Guimin Zhang, Mitali J. More, Allen R. Goode, Stan Majewski, Randy F. Wojcik, Brian Kross, Vladimir Popov, Andrew G. Weisenberger, Martin J. Stanton, Walter Charles Phillips, Alexander X. Stewart, Thomas G. McCauley, Tao Wu, and Edward V.R. DiBella "Integrated CT-SPECT system for small-animal imaging", Proc. SPIE 4142, Penetrating Radiation Systems and Applications II, (18 December 2000); https://doi.org/10.1117/12.410571

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