Relationship between position of brain activity and change in optical density for NIR imaging

Yoshihiko Kashio; Muneo Ono; Michael Firbank; Martin Schweiger; Simon Robert Arridge; Eiji Okada

doi:10.1117/12.407612

22 November 2000 Relationship between position of brain activity and change in optical density for NIR imaging

Yoshihiko Kashio, Muneo Ono, Michael Firbank, Martin Schweiger, Simon Robert Arridge, Eiji Okada

Proceedings Volume 4160, Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography: Imaging and Functional Assessment; (2000) https://doi.org/10.1117/12.407612
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

Multi-channel NIR system can obtain the topographic image of brain activity. Since the image is reconstructed from the change in optical density measured with the source-detector pairs, it is important to reveal the volume of tissue sampled by each source-detector pair. In this study, the light propagation in three-dimensional adult head model is calculated by hybrid radiosity-diffusion method. The model is a layered slab which mimics the extra cerebral tissue (skin, skull), CSF and brain. The change in optical density caused by the absorption change in a small cylindrical region of 10 mm in diameter at various positions in the brain is calculated. The greatest change in optical density can be observed when the absorber is located in the middle of the source and detector. When the absorber is located just below the source or detector, the change in optical density is almost half of that caused by the same absorber in the midpoint. The light propagation in the brain is strongly affected by the presence of non-scattering layer and consequently sensitive region is broadly distributed on the brain surface.

Citation Download Citation

Yoshihiko Kashio, Muneo Ono, Michael Firbank, Martin Schweiger, Simon Robert Arridge, and Eiji Okada "Relationship between position of brain activity and change in optical density for NIR imaging", Proc. SPIE 4160, Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography: Imaging and Functional Assessment, (22 November 2000); https://doi.org/10.1117/12.407612

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available