Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities

Quan Zhang; Thomas J. Brukilacchio; Thomas Gaudett; Lai Wang; Ang Li; David A. Boas

doi:10.1117/12.434493

29 June 2001 Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities

Quan Zhang, Thomas J. Brukilacchio, Thomas Gaudett, Lai Wang, Ang Li, David A. Boas

Author Affiliations +

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434493
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Continuous-Wave (CW) and Frequency-Domain (RF) methods of diffuse optical imaging are compared to identify the optimal approach for a clinical system. The CW Imager features fast imaging with 9 frequency-encoded sources and 16 detectors. The homodyne RF imager has 40 sources modulated at a frequency of 70 MHz and 9 detectors. Both systems incorporate two wavelengths. The features and characterization of both system are discussed and compared. A versatile phantom box design is presented that offered flexibility in experimental design and facilitated optimization of probe geometry. A 3D absorption image reconstruction phantom experiment is carried out to test the performance of the RF system. Noise models are set up and experimentally verified, and a signal-to-noise ratio analysis is presented. The heterogeneity detection sensitivity of the CW method and the RF method are compared, using both simulation and phantom experiments. The comparison results are discussed in the context of the most suitable approach to the design of a clinical breast cancer detection system.

Citation Download Citation

Quan Zhang, Thomas J. Brukilacchio, Thomas Gaudett, Lai Wang, Ang Li, and David A. Boas "Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434493

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