Biosensing with optical microcavities

Steve Blair; Yan Chen

doi:10.1117/12.427963

21 May 2001 Biosensing with optical microcavities

Steve Blair, Yan Chen

Proceedings Volume 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology; (2001) https://doi.org/10.1117/12.427963
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The artificial resonances of dielectric optical microcavities can be used to enhance the detection sensitivity of evanescent-wave optical fluorescence biosensors to the binding of a labeled analyte to a biospecific monolayer. Microcavity sensors offer the high sensitivity of a slab waveguide evanescent fluorescence sensor of much larger sensing surface area. Alternatively, when compared to a slab waveguide of the same area, microcavity based sensors offer much improved sensitivity. In either case, the required number of bound analytes is dramatically reduced. These scaling relations are highly conducive to achieving large sensing arrays with small sample volumes.

Citation Download Citation

Steve Blair and Yan Chen "Biosensing with optical microcavities", Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); https://doi.org/10.1117/12.427963

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