Glial cell adhesion and protein adsorption on SAM coated semiconductor and glass surfaces of a microfluidic structure

Darryl Y. Sasaki; Jimmy D. Cox; Susan C. Follstaedt; Mark S. Curry; Steven K. Skirboll; Paul Lee Gourley

doi:10.1117/12.427966

21 May 2001 Glial cell adhesion and protein adsorption on SAM coated semiconductor and glass surfaces of a microfluidic structure

Darryl Y. Sasaki, Jimmy D. Cox, Susan C. Follstaedt, Mark S. Curry, Steven K. Skirboll, Paul Lee Gourley

Author Affiliations +

Proceedings Volume 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology; (2001) https://doi.org/10.1117/12.427966
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The development of microsystems that merge biological materials with microfabricated structures is highly dependent on the successful interfacial interactions between these innately incompatible materials. Surface passivation of semiconductor and glass surfaces with thin organic films can attenuate the adhesion of proteins and cells that lead to biofilm formation and biofouling of fluidic structures. We have examined the adhesion of glial cells and serum albumin proteins to microfabricated glass and semiconductor surfaces coated with self-assembled monolayers of octadecyltrimethoxysilane and N-(triethoxysilylpropyl)-O- polyethylene oxide urethane, to evaluate the biocompatibility and surface passivation those coatings provide.

Citation Download Citation

Darryl Y. Sasaki, Jimmy D. Cox, Susan C. Follstaedt, Mark S. Curry, Steven K. Skirboll, and Paul Lee Gourley "Glial cell adhesion and protein adsorption on SAM coated semiconductor and glass surfaces of a microfluidic structure", Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); https://doi.org/10.1117/12.427966

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