Clinical results with UV-excited autofluorescence spectroscopy in different organs

Herbert G. Stepp; Alexander H. Hohla

doi:10.1117/12.447139

31 October 2001 Clinical results with UV-excited autofluorescence spectroscopy in different organs

Herbert G. Stepp, Alexander H. Hohla

Proceedings Volume 4432, Diagnostic Optical Spectroscopy in Biomedicine; (2001) https://doi.org/10.1117/12.447139
Event: European Conferences on Biomedical Optics, 2001, Munich, Germany

Abstract

UV-excitation with 308 nm was applied clinically to normal and diseased tissues from the urinary bladder, the brain and the lungs. With a multifiber catheter, fluorescence spectra were recorded and evaluated using the most significant wavelength ratios. Correlation with histology showed the following sensitivities / specificities for the detection of malignant tissue: bladder 90% / 81%, brain 62% / 100%, lungs 80% / 76%. Compared to 5-ALA induced PPIX-fluorescence (bladder), a higher specificity was observed. The results obtained intraoperatively were compared with UV-imaging and spectroscopy on frozen tissue sections.

Citation Download Citation

Herbert G. Stepp and Alexander H. Hohla "Clinical results with UV-excited autofluorescence spectroscopy in different organs", Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); https://doi.org/10.1117/12.447139

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