Spectroscopic studies of drugs used in the treatment of malignant tumors in ophthalmology

Mihail-Lucian Pascu; Benone D. Carstocea; Angela Staicu; Marcel A. Ionita; Sorina Truica; Ruxandra Pascu

doi:10.1117/12.446717

23 October 2001 Spectroscopic studies of drugs used in the treatment of malignant tumors in ophthalmology

Mihail-Lucian Pascu, Benone D. Carstocea, Angela Staicu, Marcel A. Ionita, Sorina Truica, Ruxandra Pascu

Proceedings Volume 4606, Laser Florence 2000: A Window on the Laser Medicine World; (2001) https://doi.org/10.1117/12.446717
Event: Laser Florence 2000: A Window on the Laser Medicine World, 2000, Florence, Italy

Abstract

Two classes of substances which may be used in the treatment of malignant tumors in ophthalmology are studied from the point of view of their spectroscopic properties: synthetic porphyrines such as TNP, TPP, TSPP and Zn-TSPP and cytostatics such as 5-fluorouracil. The absorption, excitation and fluorescence spectra of the porphyrins are measured in water and DMSO solutions to allow their efficient use in photodynamic therapy studies at irradiation with UV-laser light. A spectroscopic study of 5-fluorouracyl, a cytostatic drug used in the treatment of ophthalmologic tumors is reported. Absorption, fluorescence excitation/emission spectra were measured for solutions of 5-fluorouracyl at 5 X 10^-5 M concentration. The effects of UV-VIS irradiation of on the 5-fluorouracyl solutions were investigated. The irradiation was performed with a classical Xe lamp having a power density of 11 mW/cm², at time intervals between 15 min and 60 min. While the absorption is not affected by light irradiation, the fluorescence of the solutions is increasing with the irradiation duration.

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Mihail-Lucian Pascu, Benone D. Carstocea, Angela Staicu, Marcel A. Ionita, Sorina Truica, and Ruxandra Pascu "Spectroscopic studies of drugs used in the treatment of malignant tumors in ophthalmology", Proc. SPIE 4606, Laser Florence 2000: A Window on the Laser Medicine World, (23 October 2001); https://doi.org/10.1117/12.446717

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