Automated identification of temporal pattern with high initial enhancement in dynamic MR lesions using fuzzy c-means algorithm

Weijie Chen; Maryellen Lissak Giger; Ulrich Bick

doi:10.1117/12.535619

12 May 2004 Automated identification of temporal pattern with high initial enhancement in dynamic MR lesions using fuzzy c-means algorithm

Weijie Chen, Maryellen Lissak Giger, Ulrich Bick

Author Affiliations +

Proceedings Volume 5370, Medical Imaging 2004: Image Processing; (2004) https://doi.org/10.1117/12.535619
Event: Medical Imaging 2004, 2004, San Diego, California, United States

Abstract

In contrast-enhanced (CE) MRI of the breast, signal-intensity time curves have been proven useful in differentiating between benign and malignant lesions. Due to uptake heterogeneity in the breast lesion, however, the signal-intensity time curve obtained from a specific region in the lesion may outperform that from the entire lesion. In this study, we propose the use of fuzzy c-means (FCM) clustering algorithms to reveal different temporal patterns within the breast lesion. The algorithm finds fuzzy cluster centers (i.e., temporal patterns) and assigns membership values to each voxel. The temporal pattern with maximum initial enhancement is selected as the representative curve of the lesion and the thresholded membership map is the identified region of fast enhancement. The approach was applied to the analysis of 121 lesions (77 malignant and 44 benign). The resulting representative curves were classified with linear discriminant analysis (LDA). The differentiation performance of LDA output in leave-one-out cross evaluation was assessed using receiver operating characteristic (ROC) analysis. Our results show that the use of FCM significantly improved the performance of signal-intensity time curves in the task of distinguishing between malignant and benign lesions.

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Weijie Chen, Maryellen Lissak Giger, and Ulrich Bick "Automated identification of temporal pattern with high initial enhancement in dynamic MR lesions using fuzzy c-means algorithm", Proc. SPIE 5370, Medical Imaging 2004: Image Processing, (12 May 2004); https://doi.org/10.1117/12.535619

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