A model of hemodynamic responses of rat tumors to hyperoxic gas challenge

Mengna Xia; Ralph P. Mason; Hanli Liu

doi:10.1117/12.592291

28 April 2005 A model of hemodynamic responses of rat tumors to hyperoxic gas challenge

Mengna Xia, Ralph P. Mason, Hanli Liu

Proceedings Volume 5693, Optical Tomography and Spectroscopy of Tissue VI; (2005) https://doi.org/10.1117/12.592291
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

We measured the changes of oxy-hemoglobin (Δ[HbO2]) and deoxy-hemoglobin concentration (Δ[Hb]) in rat breast 13762NF tumors with respect to oxygen or carbogen inhalation using near-infrared spectroscopy (NIRS). The changes in tumor blood flow can be estimated from the NIRS data provided with certain model assumptions. In the theoretical approach, we modified the Windkessel model so as to associate the mathematical model with such physiological parameters of tumor vasculature as total hemoglobin concentration ([HbT]), tumor blood flow (TBF), and tumor metabolic rate of oxygen (TMRO₂). The computational results show that hyperoxic gas administration to the rat tumors always gave rise to improvement of tumor Δ[HbO₂], while the same hyperoxic gas intervention could result in different responses in tumor [HbT], TBF, and TMRO₂. This preliminary study has demonstrated that NIRS, a noninvasive tool to monitor tumor oxygenation, may also be used to estimate tumor perfusion and oxygen consumption rate in response to therapeutic interventions, if a suitable mathematical model is provided.

Citation Download Citation

Mengna Xia, Ralph P. Mason, and Hanli Liu "A model of hemodynamic responses of rat tumors to hyperoxic gas challenge", Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); https://doi.org/10.1117/12.592291

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