A spatial-temporal comparison of fMRI and NIRS hemodynamic responses to motor stimuli in adult humans

T. J. Huppert; R. D. Hoge; M. A. Franceschini; D. A. Boas

doi:10.1117/12.612143

28 April 2005 A spatial-temporal comparison of fMRI and NIRS hemodynamic responses to motor stimuli in adult humans

T. J. Huppert, R. D. Hoge, M. A. Franceschini, D. A. Boas

Proceedings Volume 5693, Optical Tomography and Spectroscopy of Tissue VI; (2005) https://doi.org/10.1117/12.612143
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Near infrared spectroscopy (NIRS) has the ability to record, at high temporal resolution, hemodynamic changes within the brain during functional activity. Although alone, NIRS has a poorer spatial resolution compared to other imaging methods such as functional MRI (fMRI), multi-modality approaches, which attempt to fuse the spatial resolution of MRI with the hemoglobin oxygenation information and temporal resolution of NIRS, show promise to yielding better insight into the hemodynamic and metabolic response of the functional brain in future research. However, paramount to the development of these multi-modality approaches, proper control experiments to validate the correlation between NIRS and fMRI methods must be preformed. In this experiment, we have examined the spatial and temporal relationship between the NIRS measure of deoxy-hemoglobin and the fMRI blood oxygen level dependent (BOLD) signal. Here, we have modeled the propagation of light through realistic, tissue segmented, head models for each of five subjects. Using these sensitivity profiles, we predicted the measurement of deoxy-hemoglobin for each individual NIRS source-detector pair from the projection of the volume-wise fMRI BOLD changes, thus allowing a quantitative spatial and temporal comparison between NIRS and fMRI. We report a linear correlation of R = 0.73 (p < 2x10 ^-8) between the spatial profiles between the NIRS measure of deoxy-hemoglobin and BOLD signal. We also report a temporal correlation of R=0.88 (p<9x10 ^-18) between the region-of-interest averaged responses using the projected BOLD response.

Citation Download Citation

T. J. Huppert, R. D. Hoge, M. A. Franceschini, and D. A. Boas "A spatial-temporal comparison of fMRI and NIRS hemodynamic responses to motor stimuli in adult humans", Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); https://doi.org/10.1117/12.612143

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