Biosensing based upon molecular confinement in metallic nanocavity arrays

Yongdong Liu; Steve Blair

doi:10.1117/12.591666

31 March 2005 Biosensing based upon molecular confinement in metallic nanocavity arrays

Yongdong Liu, Steve Blair

Proceedings Volume 5703, Plasmonics in Biology and Medicine II; (2005) https://doi.org/10.1117/12.591666
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

We study enhancement of fluorescence of molecular species bound within metallic nanocavities. These nanostructures possess a number of desirable properties for real-time microarrays, such as localization of excitation light within the nanocavities, strong isolation from fluorescence produced by unbound species,and an apparent increase in fluorescence yield for bound species. Experimental measurements show a nearly a factor of 2 increase in excitation intensity within the nanocavities, and factor of 6 increase in yield. A simple electromangetic model of a dipole within a nanocavity shows an increase in radiative output consistent with our yield estimates and also verifies the strong fluorescence isolation from species lying outside the nanocavity.

Citation Download Citation

Yongdong Liu and Steve Blair "Biosensing based upon molecular confinement in metallic nanocavity arrays", Proc. SPIE 5703, Plasmonics in Biology and Medicine II, (31 March 2005); https://doi.org/10.1117/12.591666

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