A label-free detection method of biochemical interactions with low-cost plastic and other transparent transducers

Rudiger Frank; Bernd Mohrle; Dieter Frohlich; Gunter Gauglitz

doi:10.1117/12.605431

3 June 2005 A label-free detection method of biochemical interactions with low-cost plastic and other transparent transducers

Rudiger Frank, Bernd Mohrle, Dieter Frohlich, Gunter Gauglitz

Author Affiliations +

Proceedings Volume 5826, Opto-Ireland 2005: Optical Sensing and Spectroscopy; (2005) https://doi.org/10.1117/12.605431
Event: OPTO-Ireland, 2005, Dublin, Ireland

Abstract

This article is presenting results of label-free detections of biochemical interactions with a simple optical reflectometric concept. While other label-free detection methods need special dimensioned transducers and a high device-related effort, this new principle is working with only one optimal wavelength and is getting qualitatively good results which are absolutely comparable to already established detection methods. We show among other things that it is possible to detect antigene-antibody binding as well as DNA-DNA hybridizations on low cost plastic transducers with this simple 1λ-reflectometry concept.

Citation Download Citation

Rudiger Frank, Bernd Mohrle, Dieter Frohlich, and Gunter Gauglitz "A label-free detection method of biochemical interactions with low-cost plastic and other transparent transducers", Proc. SPIE 5826, Opto-Ireland 2005: Optical Sensing and Spectroscopy, (3 June 2005); https://doi.org/10.1117/12.605431

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