Expression of fas protein on CD4+ T cells irradiated by low level He-Ne laser in the case of psoriasis

Fan Nie; Jing Zhu; Hui-guo Zhang

doi:10.1117/12.639194

11 September 2006 Expression of fas protein on CD₄⁺ T cells irradiated by low level He-Ne laser in the case of psoriasis

Fan Nie, Jing Zhu, Hui-guo Zhang

Author Affiliations +

Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 59670M (2006) https://doi.org/10.1117/12.639194
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China

Abstract

Objective: To investigate the influence on the Expression of Fas protein on CD₄⁺ T cells irradiated by low level He-Ne laser in the cases of psoriasis. Methods: the expression of CD₄⁺ T Fas protein was determined in the case of psoriasis (n=5) pre and post-low level laser irradiation (30 min, 60min and 120min) by flow cytometry as compared withthe control (n=5). Results: In the cases of psoriasis, the expression of CD₄⁺ T FAS protein 21.4±3.1% was increased significantly than that of control group 16.8±2.1% pre-irradiation, p<0.05; in the control, there is no difference between pre and post- irradiation, p>0.05; in the cases, the expression of CD₄⁺ T Fas protein wae positively corelated to the irradiation times, when the energy density arrived to 22.92J/cm² (60 minutes) and 45.84J/cm² (120minutes), the expression of CD₄⁺ T Fas protein was increased significantly as compared with pre-irradiation, p<0.05. Conclusion: The expression of CD₄⁺ T Fas protein may be increased by low level He-Ne laser irradiation, the uncontrolled status of apoptosis could be corrected.

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Fan Nie, Jing Zhu, and Hui-guo Zhang "Expression of fas protein on CD₄⁺ T cells irradiated by low level He-Ne laser in the case of psoriasis", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 59670M (11 September 2006); https://doi.org/10.1117/12.639194

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