The adjuvanticity of gold nanoparticles

Lev A. Dykman; Vladimir A. Bogatyrev; Sergey A. Staroverov; Dmitry V. Pristensky; Sergey Yu. Shchyogolev; Nikolai G. Khlebtsov

doi:10.1117/12.695006

7 July 2006 The adjuvanticity of gold nanoparticles

Lev A. Dykman, Vladimir A. Bogatyrev, Sergey A. Staroverov, Dmitry V. Pristensky, Sergey Yu. Shchyogolev, Nikolai G. Khlebtsov

Author Affiliations +

Proceedings Volume 6164, Saratov Fall Meeting 2005: Coherent Optics of Ordered and Random Media VI; 616404 (2006) https://doi.org/10.1117/12.695006
Event: Saratov Fall Meeting 2005, 2005, Saratov, Russian Federation

Abstract

A new variant of a technique for in vivo production of antibodies to various antigens with colloidal-gold nanoparticles as carrier is discussed. With this technique we obtained highly specific and relatively high-titre antibodies to different antigens. The antibodies were tested by an immunodot assay with gold nanoparticle markers. Our results provide the first demonstration that immunization of animals with colloidal gold complexed with either haptens or complete antigens gives rise to highly specific antibodies even without the use of complete Freund's adjuvant. These findings may attest to the adjuvanticity of gold nanoparticles itself. We provide also experimental results and discussion aimed at elucidation of possible mechanisms of the discovered colloidal-gold-adjuvanticity effect.

Citation Download Citation

Lev A. Dykman, Vladimir A. Bogatyrev, Sergey A. Staroverov, Dmitry V. Pristensky, Sergey Yu. Shchyogolev, and Nikolai G. Khlebtsov "The adjuvanticity of gold nanoparticles", Proc. SPIE 6164, Saratov Fall Meeting 2005: Coherent Optics of Ordered and Random Media VI, 616404 (7 July 2006); https://doi.org/10.1117/12.695006

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