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The feasibility of spatial resolved reflectometry (SRR) and time-of-flight (TOF) techniques application at the
wavelength of 820 nm for the detection of changes in optical properties of multilayer scattering medium was
considered. The model SRR and TOF signals from a 3-layer biotissue phantom mimicking two skin layers and a
blood layer between them were obtained by using Monte Carlo method. It was assumed that changes in the
glucose level induce changes only in the blood layer and the deeper skin layer. The scattering maps were
obtained in order to analyze the trajectories of the photons contributing to the signals. Different characteristics of
the TOF signal were analyzed. Relative changes of the signals induced by the glucose level variations were
analyzed for different source-detector separations. It was shown that the maximal relative change of the signal
for both techniques of about 7% corresponding to the glucose concentration change from 0 to 500 mg/dl takes
place for source-detector separations in the range from 0.3 to 0.5 mm depending on the model parameters.
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Mikhail Yu. Kirillin, Alexander V. Bykov, Alexander V. Priezzhev, Risto Myllyla, "Optical glucose sensing in biotissue phantom by diffuse reflectance technique," Proc. SPIE 6445, Optical Diagnostics and Sensing VII, 64450U (15 February 2007); https://doi.org/10.1117/12.706109