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Alcohol, which is ubiquitous today, is a major health concern. Its use was already relatively high among the youngest
respondents, peaked among young adults, and declined in older age groups. Alcohol is causally related to more than 60
different medical conditions. Overall, 4% of the global burden of disease is attributable to alcohol, which accounts for
about as much death and disability globally as tobacco and hypertension. Alcohol also promotes the generation of
reactive oxygen species (ROS) and/or interferes with the body's normal defense mechanisms against these compounds
through numerous processes, particularly in the liver. Photobiomodulation (PBM) is a cell-specific effect of low intensity
monochromatic light or low intensity laser irradiation (LIL) on biological systems. The cellular effects of both alcohol
and LIL are ligand-independent so that PBM might rehabilitate alcohol induced dysfunction. The PBM on alcohol
induced human neutrophil dysfunction and rat chronic atrophic gastritis, the laser acupuncture on alcohol addiction, and
intravascular PBM on alcoholic coma of patients and rats have been observed. The endonasal PBM (EPBM) mediated by
Yangming channel, autonomic nervous systems and blood cells is suggested to treat alcohol induced dysfunction in terms
of EPBM phenomena, the mechanism of alcohol induced dysfunction and our biological information model of PBM. In
our opinion, the therapeutic effects of PBM might also be achieved on alcoholic myopathy.
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