On selectivity and gating of ionic channels

D. G. Luchinsky; R. Tindjong; P. V. E. McClintock; I. Kaufman; R. S. Eisenberg

doi:10.1117/12.724703

8 June 2007 On selectivity and gating of ionic channels.

D. G. Luchinsky, R. Tindjong, P. V. E. McClintock, I. Kaufman, R. S. Eisenberg

Proceedings Volume 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems; 66020D (2007) https://doi.org/10.1117/12.724703
Event: SPIE Fourth International Symposium on Fluctuations and Noise, 2007, Florence, Italy

Abstract

A novel conceptual model is introduced in which ion permeation is coupled to the protein wall vibration and the later in turn modulates exponentially strongly the permeation via radial oscillations of the potential of mean force. In the framework of this model of ion-wall-water interaction we discuss problems of selectivity between alike ions and coupling of ion permeation to gating.

Citation Download Citation

D. G. Luchinsky, R. Tindjong, P. V. E. McClintock, I. Kaufman, and R. S. Eisenberg "On selectivity and gating of ionic channels.", Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 66020D (8 June 2007); https://doi.org/10.1117/12.724703

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