Correlation-based biological networks

Won-Min Song; Tomaso Aste; T. Di Matteo

doi:10.1117/12.759252

5 January 2008 Correlation-based biological networks

Won-Min Song, Tomaso Aste, T. Di Matteo

Proceedings Volume 6802, Complex Systems II; 680212 (2008) https://doi.org/10.1117/12.759252
Event: SPIE Microelectronics, MEMS, and Nanotechnology, 2007, Canberra, ACT, Australia

Abstract

We construct a correlation-based biological network from a data set containing temporal expressions of 517 fibroblast tissue genes at transcription level. Four relevant and meaningful connected subgraphs of the network, namely: minimal spanning tree, maximal spanning tree, combined graph of minimal and maximal trees, and planar maximally filtered graph are extracted and the subgraphs' geometrical and topological properties are explored by computing relevant statistical quantities at local and global level. The results show that the subgraphs are extracting relevant information from the data set by retaining high correlation coeffcients. The design principle of the underlying biological functions is reflected in the topology of the graphs.

Citation Download Citation

Won-Min Song, Tomaso Aste, and T. Di Matteo "Correlation-based biological networks", Proc. SPIE 6802, Complex Systems II, 680212 (5 January 2008); https://doi.org/10.1117/12.759252

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