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21 February 2008 Miniaturized probe using 2 axis MEMS scanner for endoscopic multiphoton excitation microscopy
Woonggyu Jung, Shuo Tang, Tiquiang Xie, Daniel T. McCormick, Yeh-Chan Ahn, Jianping Su, Ivan V. Tomov, Tatiana B. Krasieva, Bruce J. Tromberg, Zhongping Chen
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Proceedings Volume 6851, Endoscopic Microscopy III; 68510D (2008) https://doi.org/10.1117/12.764356
Event: SPIE BiOS, 2008, San Jose, California, United States
Abstract
The practical limitation of in vivo multiphoton excitation microscopy (MPM) is the lack of a compact and flexible probe. Most MPM depends on the bench-top microscope, which prohibits expansion of in vivo application. In this study, we introduced a miniaturized MPM probe using a microelectromechanical system (MEMS) scanning mirror and a doubleclad photonic crystal fiber (DCPCF). Benefits from both a MEMS mirror and a DCPCF overcome current obstacles for probe development, such as size reduction, rapid scanning, efficient delivery of short pulses, and high collection rate of fluorescent signals. In this study, the completed probe was 1 cm in outer diameter and 14 cm in length. The probe was then integrated to the MPM system and used to image fluorescent beads, paper and biological specimens.
© (2008) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Woonggyu Jung, Shuo Tang, Tiquiang Xie, Daniel T. McCormick, Yeh-Chan Ahn, Jianping Su, Ivan V. Tomov, Tatiana B. Krasieva, Bruce J. Tromberg, and Zhongping Chen "Miniaturized probe using 2 axis MEMS scanner for endoscopic multiphoton excitation microscopy", Proc. SPIE 6851, Endoscopic Microscopy III, 68510D (21 February 2008); https://doi.org/10.1117/12.764356
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Cited by 5 scholarly publications.
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KEYWORDS
Microelectromechanical systems
Mirrors
GRIN lenses
Image visualization
Endoscopy
Luminescence
Microscopy
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